Anticancer activity of Methanolic leaves extract of Avicennia officinalis on Ehrlich ascitis Carcinoma cell lines in Rodents

Cancer is a disease charecterised by abnormal or uncontrolled growth, invasion and metastasis of cells. This may be caused due to effects of carcinogens, radiations and also may be due to errors in DNA replication. The methanolic leaf extract of Avicennia officinalis[MEAO] at the dose of 200mg/kg and 400mg/kg was studied against cytotoxic effect for management of cancer, when tested on mean survival time and haematological parameters. The Ehrlich ascitic carcinoma cell lines were used for inducing cancer in mice. The MST of EAC transplanted mice was shown an increase from 14 days to 17-22 days in extract treated group when compared with control. The extract reverses the haematological changes induced by the cell lines. The extract posses cytotoxic effect in dose dependant manner and was statistically analysed by graph pad prism and was found to be highly significant. (p<0.01**)